Increased expression of the proprotein convertase enzyme FURIN in rheumatoid arthritis
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چکیده
منابع مشابه
Sox9-dependent transcriptional regulation of the proprotein convertase furin.
The proprotein convertase furin participates in the maturation/bioactivation of a variety of proproteins involved in chondrogenesis events. These include parathyroid hormone-related peptide (PTHrP), an autocrine/paracrine factor that is crucial to both normal cartilage development and cartilage-related pathological processes. Despite the known importance of furin activity in the bioactivation o...
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Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors, metalloproteases, and extracellular matrix proteins. Therefore, it has been suggested that inhibition of the ubiquitously expressed proprotein convertase FURIN might be a good therapeutic strategy for several tumor types. Whether this is a...
متن کاملMyeloid cell expressed proprotein convertase FURIN attenuates inflammation
The proprotein convertase enzyme FURIN processes immature pro-proteins into functional end- products. FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance. FURIN also promotes the infectivity of pathogens by activating bacterial toxins and by processing viral proteins. Here, we evaluated the role of FURIN in LysM+ myeloid ...
متن کاملProprotein convertase furin regulates osteocalcin and bone endocrine function.
Osteocalcin (OCN) is an osteoblast-derived hormone that increases energy expenditure, insulin sensitivity, insulin secretion, and glucose tolerance. The cDNA sequence of OCN predicts that, like many other peptide hormones, OCN is first synthesized as a prohormone (pro-OCN). The importance of pro-OCN maturation in regulating OCN and the identity of the endopeptidase responsible for pro-OCN cleav...
متن کاملIncreased Expression of the Pro-Protein Convertase Furin Predicts Decreased Survival in Ovarian Cancer
BACKGROUND Proprotein convertases (PCs) are serine proteases that after restricted proteolysis activate many proteins that play a crucial role in cancer such as metalloproteinases, growth factors and growth factor receptors, adhesion molecules, and angiogenic factors. Although the expression of several PCs is increased in many tumors, their expression in primary ovarian tumors has not been stud...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Rheumatology
سال: 2018
ISSN: 0300-9742,1502-7732
DOI: 10.1080/03009742.2018.1520294